DR. WALKER

Indirubin Many Health Benefits

Name and Origin

Indirubin is a natural compound derived from indigo plants, particularly Isatis tinctoria and Polygonum tinctorium. Traditionally used in Chinese medicine, it has garnered attention for its potential therapeutic benefits, especially in the treatment of chronic diseases.

Benefits

Indirubin is most renowned for its anti-inflammatory and anti-cancer properties. Studies have shown that it can inhibit the proliferation of various cancer cells, including leukemia and solid tumors (Lin Yang, 2022). Additionally, it has been noted for its ability to modulate the immune system, making it a promising candidate for autoimmune disorders (Yajing Zhao, 2019). Indirubin also exhibits antioxidant properties.

Expanded Health Benefits:

Here are some of the additional health benefits associated with indirubin:
 Anti-Inflammatory Properties: Indirubin has been shown to have anti-inflammatory effects, which can help in managing conditions characterized by inflammation.

 Anticancer Effects: Research suggests that indirubin may exhibit anticancer properties. It has been studied for its ability to inhibit the proliferation of cancer cells and induce apoptosis (programmed cell death) in certain types of cancer.

 Antiviral Activity: Some studies indicate that indirubin may possess antiviral properties, potentially offering protection against certain viral infections.

 Neuroprotective Effects: Preliminary research suggests that indirubin may have neuroprotective effects, which could be beneficial in neurodegenerative diseases.

 Regulation of Immune Function: Indirubin has been studied for its effects on the immune system, including the modulation of immune cell activity.

 Antioxidant Activity: It may have antioxidant properties, helping to neutralize free radicals and reduce oxidative stress in the body.

 Potential in Treating Skin Disorders: Indirubin has been used in traditional medicine for skin conditions, and some studies suggest it may help in treating conditions like psoriasis.

 Possible Role in Diabetes Management: Some research indicates that indirubin may help in regulating blood sugar levels and improving insulin sensitivity.

Other Names

Indirubin is sometimes referred to as Indigo red, coroupitine B, indigopurpurin. It is also linked to its natural source, often being called Indigo Naturalis.

Adverse Reactions

Some individuals may experience liver dysfunction, headache, and gastrointestinal discomfort, including nausea abdominal pain. Topical ointment may cause pruritus, rash, and erythema.

Contraindications

If you have gastrointestinal discomfort of any sort then before incorporating it into your treatment regiment, it is recommended to talk with a healthcare professional first.

Drug Interactions

Indirubin may interact with medications such as CYP 450 3A4 drugs, and alter how these drugs are metabolized in the body (Indirubin, 2022).

Dose

Since there is no sufficient data yet available to provide a recommended dose, therefore it is important to consult a healthcare provider for personalized dosing information.

References:

Indirubin. (2022, May 5). Retrieved from Memorial Sloan Kettering Cancer Center:
Lin Yang, X. L. (2022). Pharmacological properties of indirubin and its derivatives. Biomedicine & Pharmacotherapy.
Yajing Zhao, P. H. (2019). Indirubin modulates CD4+ T‐cell homeostasis via PD1/PTEN/AKT signalling pathway in immune thrombocytopenia. Journal of Cellular and Molecular Medicine.