Vitamin D, (also referred to as calciferol) is a fat-soluble vitamin and is an essential precursor to an active hormonal form that is an important regulator of numerous health conditions. Colloquially described as “the sunshine vitamin,” it is actually a steroid with hormone-like activity. D3 is produced in the skin in response to sunlight and is converted to the active form via sunlight exposure of unprotected skin to ultraviolet B radiation. It is also found in some animal-based foods and is often available as a dietary supplement. Sunshine is the best source, but various factors limit adequate D absorption from sun exposure (age, skin tone, geographic location, time of year, infection, etc.). Vitamin D has receptors found in almost all types of cells in the body, from our head to our toes have vitamin D receptors on their surface. It binds to the membrane vitamin D receptor or the nuclear vitamin D receptor and elicits specific biological responses. Vitamin D regulates functions of over 200 genes in our body. It is responsible for increased absorption of calcium and phosphorus and is essential for maintaining healthy bones and teeth, supporting immune system function, and regulating calcium and phosphorus levels in the blood.
Can Vitamin D Protect Against Cancer?
The relationship between vitamin D levels and cancer prevention is a topic of ongoing discussion. It is known that adequate vitamin D levels is associated with a reduced risk of certain types of cancer. A 2005 study found that women with blood concentrations of vitamin D higher than 60ng/ml had an 83% reduction in breast cancer compared with those lower than 20ng/ml; ostensibly, men has the same anti-cancer benefits from vitamin D. Another study suggested that achieving 80 ng/mL of vitamin D may reduce cancer incidence rates by 70%. Vitamin D supplementation has been associated with reduced total cancer mortality risk. Despite this, a study in 2016 amongst Dutch athletes showed two thirds of people are below the danger level of 30 ng/ml. Research estimates that up to 42% of Americans have a vitamin D deficiency, 82% of black Americans and 69% of Hispanic Americans are deficient. In “CANCERactive” patients, some providers encourage the base of 60 ng/ml with, ideally, levels over 75 ng/ml and up to 150 ng/ml.
Which Cancers Does Vitamin D Helps Protect Against?
Here are six types of cancer that studies have indicated may be influenced by vitamin D levels:
❖ Colorectal Cancer: Numerous studies have found a link between higher vitamin D levels and a reduced risk of colorectal cancer. Vitamin D may play a role in regulating cell growth and differentiation in the colon. Higher vitamin D levels have been consistently associated with reduced risks of colorectal cancer and bladder cancer.
❖ Breast Cancer: Some research suggests that higher vitamin D levels may be associated with a lower risk of breast cancer. Vitamin D may influence tumor growth and proliferation in breast tissue. Studies show that those with the highest levels of vitamin D in their blood had a significant decrease risk, especially, with regards to breast cancer risk compared with women with the lowest levels of vitamin D in their blood. Women with vitamin D concentrations ≥60 ng/ml had an 80% lower risk of breast cancer compared to women with concentrations <20 ng/ml.>
❖ Prostate Cancer: The efficacy of vitamin D for inhibiting prostate cancer cells in cell culture and animal models is well documented. Prostate cells contain vitamin D receptors and enzymes necessary for vitamin D metabolism. There is evidence to suggest that adequate vitamin D levels may be linked to a reduced risk of aggressive forms of prostate cancer. Studies have shown varying results, but some indicate that lower vitamin D levels may be associated with increased risk. What is also known is that vitamin D inhibits the production of inflammatory cytokines. The anti-inflammatory nature of vitamin D has a protective role against progression of prostate cancer.
❖ Lung Cancer: Lung cancer is one of the most malignant tumors that threatens humans. Several clinical studies have revealed the beneficial role of vitamin D in both preventing and treating lung cancer. Some studies have suggested a protective effect of vitamin D against lung cancer, particularly in individuals with adequate levels. Studies have also indicated that low serum vitamin D concentrations may increase the likelihood of developing lung cancer by over threefold.
❖ Pancreatic Cancer: Some epidemiological studies have indicated that higher vitamin D levels may be associated with a lower risk of pancreatic cancer. Vitamin D is also associated with lower risks of cardiovascular disease, age-related cognitive impairment, and other cancers.
❖ Esophageal Cancer: Vitamin D may have a role in reducing the risk of esophageal cancer. Emerging research has suggested a link between vitamin D levels and the risk of esophageal cancer, with some studies indicating that higher levels might be associated with a lower risk. Achieving a vitamin D level of 80 to 100 ng/mL may reduce cancer incidence rates by 70% by one report.
These Help to Maximize Vitamin D levels:
Here are some key supplements that can complement vitamin D:
Calcium: Calcium is essential for bone health, and vitamin D helps improve calcium absorption in the intestines. Consuming calcium-based foods with vitamin D can help support bone density and overall skeletal health.
➢ Magnesium: Magnesium plays a crucial role in the conversion of vitamin D into its active form in the body. Magnesium is essential for activating vitamin D and helping the body use it effectively. Without adequate magnesium levels, Vitamin D remains stored and inactive for as many as 50 percent of Americans. Additionally, a person's calcium and phosphate levels can continue to rise even while they remain Vitamin D deficient, if magnesium is low. Adequate magnesium levels are important for optimal vitamin D metabolism and function.
➢ Vitamin K2: Vitamin K2 works synergistically with vitamin D to help regulate calcium in the body. While vitamin D promotes calcium absorption, vitamin K2 helps direct calcium to the bones and teeth, reducing the risk of arterial calcification.
➢ Omega-3 Fatty Acids: Omega-3s, such as those found in fish oil, are known for their anti-inflammatory properties and may work well with vitamin D to support heart health and reduce inflammation.
➢ B Vitamins: While not a direct complement to vitamin D, B vitamins (especially B6, B12, and folate) support overall metabolic health and can help maintain energy levels, which may be beneficial when taking vitamin D.
Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The contents of this website are based upon the views of Dr. Walker and his experience. This product is not intended as medical advice nor to diagnose, treat, cure or prevent any disease. The information is likewise not to replace the advice of a qualified health care provider. The information provided herein is intended as a sharing of general knowledge only and is not intended to be, nor is it, medical advice or a substitute for medical advice. That being said, please consult your healthcare provider before using supplements or providing supplements to children under the age of 18. If you have or suspect you have, a specific medical condition or disease, please consult your healthcare provider.
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