Breast cancer (BC) is the most common invasive cancer in women, and it continues to be a worldwide medical problem since the number of cases has significantly increased over the past decades. Breast cancer is a complex disease that requires multidisciplinary management as well as a tailored therapy plan depending on the stage, histologic subtype, and prognostic tumor marker status. Current modalities for treating breast cancer include local therapy such as surgery and radiation therapy as well as systemic therapy including chemotherapy, endocrine, and biologic therapy.
How to reduce the risk of Breast CA
i. Vitamin D3: Research also suggests that having low vitamin D levels may increase your chances of getting certain types of cancer, including breast cancer. According to the study, those with the highest levels of vitamin D in their blood had a 45 percent decrease in breast cancer risk compared with women with the lowest levels of vitamin D in their blood. Another study strongly associates higher vitamin D levels at diagnosis with better survival rates among women with breast cancer.
ii. Green tea and Epigallocatechin Gallate (EGCG):
• Anti-angiogenesis: Taken together, inhibition of VEGF transcription appeared to be one of the molecular mechanisms involved in the antiangiogenic effects of green tea, which may contribute to its potential use for breast cancer treatment and/or prevention. All these proteins have been demonstrated to be important for the inhibitory activity of EGCG in breast cancer cell lines or animal models.
• Inhibition of cell signaling pathways: VEGF is a significant regulator in tumor angiogenesis and is overexpressed in breast cancer. Green tea catechins, especially EGCG, inhibit tumor growth, proliferation, migration, and angiogenesis of breast cancer.
• Induction of cell cycle arrest and apoptosis: Green tea extracts and EGCG are capable of inhibiting cell growth and inducing apoptosis via a variety of mechanisms. EGCG induces apoptosis in estrogen receptor-negative.
iii. Curcumin: It has been found that curcumin inhibits the migratory activity of breast cancer cells, proliferative rate, adhesion, and invasion by down-regulating the expression of NF-κBp65. Research studies show that the type of fat in the diet may affect breast cancer risk. Fish oil and fish contain increased amounts of omega-3 fatty acids which appear to stop or slow down the growth and development of breast cancer cells in laboratory studies of mice and breast cancer cells.
iv. Omega-3: Omega-3 fatty acids, specifically in premenopausal women and obese women who consume more of these healthy fats, had a lower risk of developing BC. Omega-3s seem to fight cancer development due to their ability to reduce inflammation and effects of too much estrogen. Eating fish or taking fish oil may increase the amount of omega-3 in the breast, which may lower one’s risk of breast cancer development.
Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The contents of this website are based upon the views of Dr. Walker and his experience. This product is not intended as medical advice nor to diagnose, treat, cure or prevent any disease. The information is likewise not to replace the advice of a qualified health care provider. The information provided herein is intended as a sharing of general knowledge only and is not intended to be, nor is it, medical advice or a substitute for medical advice. That being said, please consult your healthcare provider before using supplements or providing supplements to children under the age of 18. If you have or suspect you have, a specific medical condition or disease, please consult your healthcare provider.
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